Sample Resequencing Stats
Note: The mutation counts shown below represent unfiltered mutation sets.
| ALE, Flask, Isolate |
Predicted Mutations |
Mean Coverage |
Total Reads |
Percent Mapped |
Mapped Reads |
Average Read Length |
|
A5 F50 I2 R1
|
139 |
64.5 |
2139856 |
92.7% |
1983646 |
149.9 |
Breseq alignment
BRESEQ :: Evidence
|
| evidence |
seq id |
position |
mutation |
annotation |
gene |
description |
| RA |
NC_000913 |
3,915,448 |
(G)6→7 |
intergenic (‑248/+105) |
glmU ← / ← atpC |
fused N‑acetyl glucosamine‑1‑phosphate uridyltransferase/glucosamine‑1‑phosphate acetyl transferase/F1 sector of membrane‑bound ATP synthase, epsilon subunit |
| |
seq id |
position |
ref |
new |
freq |
score (cons/poly) |
reads |
annotation |
genes |
product |
| * | NC_000913 | 3,915,442 | 1 | . | G | 92.5%
| 183.3
/ 7.7
| 53 | intergenic (‑242/+111) | glmU/atpC | fused N‑acetyl glucosamine‑1‑phosphate uridyltransferase/glucosamine‑1‑phosphate acetyl transferase/F1 sector of membrane‑bound ATP synthase, epsilon subunit |
| Reads supporting (aligned to +/- strand): ref base . (1/3); new base G (26/23); total (27/26) |
| Fisher's exact test for biased strand distribution p-value = 3.51e-01 |
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 1.00e+00 |
GTTCAATAACGGATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑GGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGTCAACTCGATA > NC_000913/3915294‑3915580
|
gTTCAATAACGGATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑gg > 1:994065/1‑151 (MQ=255)
tCAATAACCGATTTTCCCCGCTGACGAAAGCCCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑gg < 2:709936/149‑1 (MQ=255)
aaTAACGGATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑gggggg < 1:428023/151‑1 (MQ=255)
aaCGGATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑gggggggt < 1:320068/150‑3 (MQ=255)
aaCGGATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑GGGGGG‑gtt < 2:707359/151‑1 (MQ=255)
tgATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑GGGGGG‑gtttt > 2:53066/2‑149 (MQ=255)
ggATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑GGGGGG‑gtttta < 1:971586/151‑3 (MQ=255)
gATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAACCAGGAAAACAGGGGGGG‑TTTtat > 2:32431/1‑151 (MQ=255)
tATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTatat < 2:556646/150‑1 (MQ=255)
tATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATc > 1:745218/1‑151 (MQ=255)
aTCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATc < 1:148252/150‑1 (MQ=255)
ccGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATcagcag < 1:736229/151‑1 (MQ=255)
gCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAgg > 2:382769/1‑150 (MQ=255)
gACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATc < 2:1063657/150‑1 (MQ=255)
gACGAAAGCGCCATTTTCGACCAGCGTCACGCCTGTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGAt < 2:589331/149‑1 (MQ=255)
cGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTAt > 2:1068521/1‑151 (MQ=255)
gAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTAtg < 2:887355/151‑1 (MQ=255)
cATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGa < 2:622654/146‑1 (MQ=255)
ttttCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTAt > 2:155900/1‑151 (MQ=255)
cGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTc > 1:896199/1‑149 (MQ=255)
aCCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGa < 1:967761/151‑1 (MQ=255)
cATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACg < 1:786638/151‑1 (MQ=255)
aTCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACgg < 1:746533/151‑1 (MQ=255)
cGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCacac > 1:1033364/1‑151 (MQ=255)
ttGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCa < 1:1027292/150‑1 (MQ=255)
cTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCaaaaa > 1:715711/1‑150 (MQ=255)
gCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCaaaaaaaa < 1:590982/151‑1 (MQ=255)
gCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCaaaaaaa > 1:13593/1‑150 (MQ=255)
aaaTTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAagcc > 2:64370/1‑149 (MQ=255)
aaTTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAagccagc < 2:910531/151‑1 (MQ=255)
aCCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGAc > 2:818917/1‑151 (MQ=255)
cTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTg > 1:986527/1‑151 (MQ=255)
tttAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCttt > 1:594761/1‑151 (MQ=255)
aGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCACTGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTtgtg > 2:158830/1‑151 (MQ=255)
cGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCt < 1:1015308/151‑1 (MQ=255)
cGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCt < 1:832656/151‑1 (MQ=255)
tCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCttt > 1:705501/1‑151 (MQ=255)
aGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTc > 1:452510/1‑151 (MQ=255)
ggATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGc > 2:899920/1‑151 (MQ=255)
gTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCgg < 1:917185/150‑1 (MQ=255)
tttttGCTCTTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGgtg > 1:160549/1‑151 (MQ=255)
tctTATTTCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATc > 1:134669/1‑151 (MQ=255)
tttCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCtt < 2:16041/150‑1 (MQ=255)
ttCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCttt < 1:137587/150‑1 (MQ=255)
tCGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCttttt > 1:1007350/1‑151 (MQ=255)
cGATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCttttt < 2:104518/150‑1 (MQ=255)
gATCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGATCGTTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTg < 2:668136/151‑1 (MQ=255)
aTCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTgg > 2:818824/1‑151 (MQ=255)
tCAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGt > 1:166644/1‑151 (MQ=255)
cAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGt > 1:455161/1‑150 (MQ=255)
cAATGAATAAACAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGTc > 1:83471/1‑151 (MQ=255)
aaTAAACAGGAAAACA‑GGGGGGTTTTTATATCGGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGTCAACt < 1:329053/150‑1 (MQ=255)
tAAACAGGCAAACAGGGGGGG‑TATTATATCAGAAGGACCTATGTGAACGCTACTCAGTTCGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGATTGGGTTTTGATCTTTTCAAGCAGGTGTTACATCGCTTTTTTGGCAAACTc > 2:560356/1‑149 (MQ=255)
aaaCAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGTCAACTCGAt < 1:625344/151‑1 (MQ=255)
aaaCAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGTCAACTCGAt < 1:672102/151‑1 (MQ=255)
aaCAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGTCAACTCGATa < 2:745177/151‑1 (MQ=255)
aCAGGAAAACAGGGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGTCAACTCGATa > 2:539058/1‑150 (MQ=255)
|
GTTCAATAACGGATTATCCCCGCTGACGAAAGCGCCATTTTCGACCATCGTCACGCCTTTTGTCTGCAGAAAATTAAGGCAGTACCTTAATTTAAGCGTCAGGTGGATGTTTTTGCTCTTATTTCGATCAATGAATAAACAGGAAAACA‑GGGGGG‑TTTTATATCAGCAGGATCTATGTGAACGCTATTCAGGACGGGTCACACGCGCAAAAAAAAGCCAGCCTGTTTCCAGACTGGCTTTTGTGCTTTTCAAGCCGGTGTTACATCGCTTTTTTGGTCAACTCGATA > NC_000913/3915294‑3915580
|
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 16 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 37 ≤ ATCG/ATCG < 39 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |
GATK/CNVnator alignment
N/A